Phosphopantetheine-binding protein

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August undefined, 2024

WebPlease help us improve further — take a moment to fill our brief user survey. WebJan 3, 2024 · Using E. coli LipB as a prototype, we show that the enzyme mainly recognizes the 4’-phosphopantetheine tethered acyl-chain of its donor substrate, and weakly binds the apo-acyl carrier protein. It can accept octanoate-from its own ACP, noncognate ACPs, as well as C 8 -CoA.

Phosphopantetheine Adenylyltransferase: A promising drug target …

WebOct 23, 2013 · The results suggest that some type I domains covalently incorporated in multidomain contexts possess potential protein binding sites missing in the equivalent regions of their respective structural templates. ... This 1136 residue long sequence is atypical since it does not possess a recognizable phosphopantetheine binding domain … WebThe mitochondrial acyl carrier protein (human ACPM, yeast Acp1) is an essential mitochondrial protein. Through binding of nascent acyl chains on the serine (S112)-bound 4′-phosphopantetheine (4′-PP) cofactor, ACPM is involved in mitochondrial fatty acid synthesis and lipoic acid biogenesis. Recently, yeast A Molecular Pharmacology floppy ones

Phosphopantetheine-binding protein (Salinispora tropica)

WebFeb 1, 2024 · The reaction mechanism of PPAT involves a nucleophilic attack by 4′-phosphate of phosphopantetheine on the α-phosphate of ATP in an in-line displacement … WebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production. WebMay 30, 2024 · FIGURE 2.(A) Structural superposition of apo Mab PPAT in complex with feed-back inhibitor CoA (grey), PDB code 7YXZ and product dpCoA (green), PDB code 5O08, showing conformational differences in the enzyme and ligand binding mode.(B) The pantetheine moiety of CoA adopts a similar conformation to that of dpCoA. However, the … floppy office

Structure, function and dynamics in acyl carrier proteins

WebJul 21, 2024 · The phosphopantetheine-binding domain (PP-binding superfamily), conserved in ACP proteins, is the prosthetic group of ACP, which acts as a linker for the attachment of the activated FA and amino acid groups via a phosphodiester bond ( Crawford et al. 2008; Meier et al. 2010; Roujeinikova et al. 2002 ). WebSep 29, 2024 · A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and … great river medical center careersWebUsing Escherichia coli LipB as a model enzyme, we show here that the octanoyl-transferase mainly recognizes the 4'-phosphopantetheine-tethered acyl-chain of its donor substrate … great river medical center employment

"WebMar 3, 2006 · In most bacteria, the so-called Dfp proteins catalyze the synthesis of the coenzyme A precursor 4′-phosphopantetheine. Dfp proteins are bifunctional enzymes catalyzing the synthesis of 4′-phosphopantothenoylcysteine (CoaB activity) and its decarboxylation to 4′-phosphopantetheine (CoaC activity). ... (maltose-binding protein) … " - Phosphopantetheine-binding protein

Phosphopantetheine-binding protein

Phosphopantetheine Adenylyltransferase: A promising drug target …

WebJul 1, 2003 · Phosphopantetheine adenylyltransferase (PPAT) regulates the key penultimate step in the essential coenzyme A (CoA) biosynthetic pathway. PPAT catalyzes the reversible transfer of an adenylyl group from Mg2+:ATP to 4′-phosphopantetheine to form 3′-dephospho-CoA (dPCoA) and pyrophosphate. WebProteomics of Streptococcus mutans to Reveal the Antibiofilm Formation Mechanism of Ag/ZnO Nanocomposites with Light-Emitting Diode Radiation

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WebIts deduced protein was most related to mouse U26. Thus, we termed it human U26. This putative protein contains an AMP-binding domain, a Phosphopantetheine-binding … WebOct 15, 2012 · Crystal Structure of Free-Standing Peptidyl Carrier Protein from Uncharacterized Acinetobacter baumannii Secondary Metabolic Pathway. ... PHOSPHOPANTETHEINE BINDING PROTEIN; Organism(s): Acinetobacter baumannii AB307-0294; ... Phosphopantetheine attachment site family protein: A, B: 88: …

WebJan 8, 2024 · 4'-Phosphopantetheine and long acyl chain-dependent interactions are integral to human mitochondrial acyl carrier protein function 4'-Phosphopantetheine and long acyl … WebThe OUROBOROS and SAMSARA proteins heterodimerise in a similar manner to TALE HD TF life cycle regulators in the green lineage. These observations demonstrate that TALE-HD-TF-based life cycle regulation systems have an extremely ancient origin, and that these systems have been independently recruited to regulate sporophyte developmental ...

WebPhosphopantetheine adenylyltransferase (PPAT, EC. 2.7.7.3) catalyzes an essential step in the reaction that transfers an adenylyl group from adenosine tri phosphate (ATP) to 4' … WebJun 3, 2010 · Phosphopantetheine Adenylyltransferase from Mycobacterium tuberculosis in complex with 4'-phosphopantetheine. ... Find proteins for P9WPA5 (Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)) Explore P9WPA5 . Go to UniProtKB: P9WPA5. Entity Groups Sequence Clusters:

Webphosphopantetheine-binding protein: copy AA seq copy Nt seq. PpisJ2_010100002376; WP_010369400.1; 206556 - 208052 (+) AMP-binding protein: copy AA seq copy Nt seq. PpisJ2_010100002381; WP_010369404.1; 208045 - 210228 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein: copy AA seq

Webprotein Summary Phosphopantetheine-binding protein (Streptomyces rimosus subsp. rimosus ATCC 10970) Cite Download Contents 1 Sequence 2 Interactions and Pathways 3 … great river medical center gymWebJul 31, 2014 · Acyl carrier proteins (ACPs) are universal and highly conserved domains central to both fatty acid and polyketide biosynthesis. These proteins tether reactive acyl intermediates with a swinging 4′-phosphopantetheine (Ppant) arm and interact with a suite of catalytic partners during chain transport and elongation while stabilizing the growing … floppy orchid flowersWebOct 29, 2024 · The brain abnormalities are fully corrected at the level of gene expression, protein quantity, and enzyme activity following the oral administration of 4′-phosphopantetheine. These changes in gene expression represent a pharmacodynamic biomarker set that can serve for the preclinical development of PKAN therapeutics. floppy outdoor hatWebThe mitochondrial acyl carrier protein (human ACPM, yeast Acp1) is an essential mitochondrial protein. Through binding of nascent acyl chains on the serine (S112)-bound … floppy paperwhitesWebApr 26, 2024 · This protein belongs to the phosphopantetheine attachment site (IPR006162) and other protein classes of databases InterPro, pfam, and TIGRfam like srf AA. The genome also possesses gene srf AD (729 bp) encodes for the thioesterase domain-containing protein comprising 242 amino acids. great river medical center burlingtonWebPhosphopantetheine-binding site.: (A) Structural superposition of ATP-bound MsFadD32 and adenylate analog- and phosphopantetheine-bound PA1221 protein. The N- and C-terminal domains of... great river medical center gym blytheville arWebBinding to a protein. ... 4'-Phosphopantetheinyl transferases (PPTs) catalyze the transfer of 4'-phosphopantetheine (4-PP) from coenzyme A to a conserved serine residue of their protein substrates. In humans, the number of pathways utilizing the 4-PP post-translational modification is limited and may only require a single broad specificity PPT ... great river medical center physical therapy