WitrynaSupporting: 24, Contrasting: 2, Mentioning: 223 - Endotoxin-induced cholestasis is mainly caused by an impaired canalicular secretion. Mrp2, the canalicular multispecific organic anion transporter, is strongly downregulated in this situation, and canalicular bile salt secretion is also reduced. We hypothesized that other adenosine triphosphate … WitrynaAbstract. Common to all so far functionally characterized Organic Anion Transporters (OATs) is their broad substrate specificity and their ability to exchange extracellular …
Dynamics of Organic Anion Transporter-Mediated Tubular …
WitrynaA number of organic acids and bases are secreted by nonspecific mechanisms. Penicillin is lost from the body fluids because of tubular secretion. ... This property of the proximal tubule to reabsorb a consistent fractional amount of glomerular filtrate is known as glomerulo- tubular balance. If the GFR is low, only a fractional amount of ... WitrynaBackground: Organic anion transporters (OATs) are located on either the basolateral or the apical membrane of the proximal tubule cell and mediate the absorption and secretion of various drugs and endogenous metabolites. It has been shown that cellular damage in acute kidney injury (AKI) involves three forms of injury: sublethal damage … pure love only for china
Dual pathways for organic anion secretion in renal proximal tubule
WitrynaThe “classical” organic anion secretory pathway of the renal proximal tubule is critical for the renal excretion of the prototypic organic anion, para-aminohippurate, as well as of a large number of commonly prescribed drugs among other significant substrates. Organic anion transporter 1 (OAT1), originally identified as NKT (Lopez-Nieto, C. E., Witryna8 kwi 2015 · The kidney is comprised of working units known as nephrons, which are epithelial tubules that contain a series of specialized cell types organized into a precise pattern of functionally distinct segment domains. There is a limited understanding of the genetic mechanisms that establish these discrete nephron cell types during renal … Witryna1 lip 2024 · we report that proximal tubule cells in kidneys sense elevated endogenous, gut microbiome-derived, metabolite levels through EGF receptors and downstream signaling to induce their secretion by up-regulating the organic anion transporter-1 (OAT1). Remote metabolite sensing and signaling was observed in kidneys from section 31 of the income tax act