Lactate chemoresistance
WebMay 5, 2014 · The lactate secretion in Glc-depleted and complete media indicates that in both OVCAR3 and SKOV3 cancer cells, Glc is the major source of lactate (Fig 3G). There were significantly lower levels of M3 pyruvate, M3 lactate and M6 citrate, from U- 13 C 5 Gln, than M3 pyruvate, M3 lactate and M2 citrate, from 1:1 mixture of U- 13 C 6 Glc and 1- 13 ... WebSep 22, 2024 · Chemoresistance Due to Changes in TME Several mechanisms and biological processes are responsible for the poor response of glioblastoma to …
Lactate chemoresistance
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WebOct 19, 2024 · lactate and lactate intrinsic activity as an HDAC inhibitor in the development of an anticancer therapy-resistant tumor phenotype, with special focus on cervical cancer … WebAug 28, 2024 · The lactate receptor, also known as hydroxycarboxylic acid receptor 1 (HCAR1/GPR81), plays a vital role in cancer biology. Recently, HCAR1 was reported to enhance metastasis, cell growth, and...
WebFeb 25, 2024 · Paclitaxel is a commonly used chemotherapy drug in the treatment of TNBC to which patients commonly develop resistance ( 44 ). Studies have reported the relationship between lactate dehydrogenase A (LDHA) and paclitaxel resistance. WebJun 1, 2024 · Lactate promotes chemoresistance through its G-protein coupled receptor GPR81 (lactate receptor/ h ydroxy c arboxylic a cid r eceptor-1; HCAR-1). HCAR-1 …
WebJun 1, 2024 · Lactate promotes chemoresistance through its G-protein coupled receptor GPR81 (lactate receptor/ h ydroxy c arboxylic a cid r eceptor-1; HCAR-1). HCAR-1 … WebApr 5, 2024 · Collectively, our findings suggest that B7-H3 may be a novel regulator of glucose metabolism and chemoresistance via controlling HK2 expression in CRC cells, a result that could help develop...
WebAccordingly, knock-down of MCT1 or application of the specific MCT1-lactate import inhibitor decreased the chemoresistance of these PDAC cells. In line with the fact that refractoriness to chemotherapy is a hallmark associated with cancer stemness [ 41 , 42 , 43 ], we could further show that MCT1-driven lactate uptake favors stemness properties.
WebMar 4, 2024 · Lactate concentration was determined with a Lactate Assay Kit (Millipore SIGMA) following the manufacturer's instruction. Measurement of Energy Metabolism in Cells A549 lung cancer cells were seeded in the lower chamber, and M2 macrophages were seeded in transwell inserts. avalon hotel spa alpharettaWebDec 6, 2024 · Physiological chemoresistance is due to poor tissue vascularization in the tumor tissue caused by the overproduction of ECM proteins and the consequent increased interstitial fluid pressure, which together produce a … le lakotaWebNov 7, 2024 · Considering that MCTs cotransport lactate and protons according to the concentration gradient, both high lactate and low pH in the TME seem to be ... Kania K.D., Blauz A., Ciszewski W.M. The lactate receptor (HCAR1/GPR81) contributes to doxorubicin chemoresistance via ABCB1 transporter up-regulation in human cervical cancer HeLa … avalonia ruhrtalWebCurcumin circumvent lactate-induced chemoresistance in hepatic cancer cells through modulation of hydroxycarboxylic acid receptor-1. Curcumin has been demonstrated to … avalon ihonpuhdistusWebApr 29, 2024 · Chemoresistance, both acquired and primary, is proven to be associated with complex multifactorial processes such as increased drug efflux, reduced drug uptake, … leland mississippiWebApr 10, 2024 · This led to decreases of double-strand breaks (DSB) and acquisition of chemoresistance. PKM2 was found to interact with octamer-binding transcription factor (OCT)-4 and enhanced OCT-4-mediated transcription . OCT-4 is a transcription factor involved in the maintenance of the pluripotent potential of embryonic stem cells and … leland jackson syracuse nyWebSep 19, 2024 · Therefore, it is believed that targeting the aspects of glucose metabolism mentioned above could lead to novel therapeutic options. More specifically myeloma cells mainly enhance glycolysis and lactate production instead of TCA cycle activation. This results in tumor growth, myeloma survival and, finally, chemoresistance. avalonia ui styles