Diacylglycerol kinases in cancer
WebApr 14, 2024 · Diacylglycerol kinase α and ζ (DGKα/ζ) metabolize the diacylglycerol generated following antigen recognition by T lymphocytes. Enhanced expression of these two lipid kinases in tumor-infiltrating CD8 + T cells promotes a hyporesponsive state that contributes to tumor immune escape. Inhibition of these two enzymes might thus be of … WebFeb 28, 2024 · Thus, diacylglycerol kinases constitute a critical node in signal transduction and a fascinating target for novel therapies. In particular, the increasing number of proteins that are known to be regulated either by diacylglycerol or by phosphatidic acid maintain the great interest in those enzymes. ... DGKs control cancer cell survival ...
Diacylglycerol kinases in cancer
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WebGarcia-Bermejo, M. L. et al. Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCα. J. Biol. WebOct 16, 2024 · Diacylglycerol (DG) kinase (DGK) phosphorylates DG to generate phosphatidic acid (PA). The α isozyme is activated by Ca2+ through its EF-hand motifs and tyrosine phosphorylation. DGKα is highly …
WebProteins that appear to be regulated, in part, by DGKs include protein kinase Cs, RasGRPs, and phosphatidylinositol kinases. By modulating the activity of these proteins, DGKs … WebOct 13, 2024 · C1 domains, cysteine-rich modules originally identified in protein kinase C (PKC) isozymes, are present in multiple signaling …
WebJul 1, 2024 · Abstract. Diacylglycerol kinases (DGKs) are integral components of signal transduction cascades that regulate cell biology through phosphorylation of the ubiquitous secondary messenger diacylglycerol. Emerging clinical evidence supports DGK-alpha (DGKA) as a promising target for cancer immunotherapy because of its critical role in … WebSep 5, 2024 · Novel therapeutic drugs with better anti-cancer effects and fewer side effects are therefore required for patients with unresectable HCC. Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to generate phosphatidic acid, which in turn plays important roles in intracellular signal transduction.
WebMar 1, 2016 · The α-isozyme enhances the proliferation of cancer cells. However, DGKα facilitates the nonresponsive state of immunity known as T-cell anergy; therefore, DGKα …
WebDiacylglycerol kinases alpha and zeta are up-regulated in cancer in cancer, and contribute towards tumor immune evasion and T cells clonal anergy. (Review) DGKalpha isoform is highly expressed in the nuclei of human erythroleukemia cell line K562, and its nuclear activity drives K562 cells through the G1/S transition during cell cycle progression. imperial fire and casualty ins companyWebJun 13, 2013 · After its generation, DAG is actively metabolized into phosphatidic acid by one of the 2 isoforms of diacylglycerol kinases (dgk) present within T cells, dgkα or dgkζ . Previously, we and others observed that deletion of either dgk isoform potentiates DAG-mediated Ras and extracellular signal-regulated kinase (ERK) activation and augments … imperial financial technology mscWebDiacylglycerol kinase alpha. DGK alpha is an enzyme that catalyzes the conversion of diacylglycerol to phosphatidic acid, thus regulating the level of these substances in the cell [4]. Diacylglycerol kinase alpha acts as a central switch between signaling pathways activated by secondary messengers such as DAG and phosphatidic acid [4]. litcharts wolf hollowWebRNA polymerase II (also called RNAP II and Pol II) is an enzyme found in eukaryotic cells. It catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA. In humans, RNAP II consists of seventeen protein molecules (gene products encoded by POLR2A-L, where the proteins synthesized from POLR2C, POLR2E, and … litcharts woman warriorWebstructure summary. Diacylglycerol kinase (DGK or DAGK) is a family of enzymes that catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA), utilizing … imperial finish body worksWebApr 10, 2024 · Background Antibody-based therapies blocking the programmed cell death-1/ligand-1 (PD-1/PD-L1) axis have provided unprecedent clinical success in cancer treatment. Acquired resistance, however, frequently occurs, commonly associated with the upregulation of additional inhibitory molecules. Diacylglycerol kinase (DGK) α limits the … lit charts wwtbgnWebJul 10, 2013 · Although diacylglycerol kinase α (DGKα) has been linked to several signaling pathways related to cancer cell biology, it has been neglected as a target for cancer therapy. The attenuation of DGKα … imperial fire alarm \u0026 security inc